The glamour clash, produced by Torneos y Competencias and World Eleven, will take place on Tuesday 18 November (kick-off 19:45 GMT) and could feature the Reds' current no.7 Angel Di Maria and a man who previously wore the shirt with such distinction, Cristiano Ronaldo.
Marcos Rojo and Nani, who is on loan at Sporting Lisbon after the two players swapped clubs in the summer, may also be on opposing sides at the Theatre of Dreams.
With Barcelona superstar Lionel Messi also potentially playing for World Cup finalists Argentina, it's likely to be another night to remember under the Old Trafford floodlights.
Participants from Manchester United Foundation projects will also be in attendance as international football returns to Manchester.
Tickets can be booked online here.